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elegans treated with 1.4 mM MPP+ at the L1 stage display developmental delays and exhibit an uncoordinated behavioral phenotype (twitcher and coiler) 3 days after treatment compared to untreated controls (Braungart et al., cat-2::GFP animals with 1.0 and 1.5 mM MPP+, degenerated dopaminergic neurons and led to reduced mobility (Braungart et al., 6-OHDA was first isolated in the 1950s (Senoh and Witkop, 1959

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